February 27, 2018
Atheendar S. Venkataramani, MD, PhD, Maheer Gandhavadi MD, Anupam B. Jena, MD, PhD
Question Is regular participation as a player in the National Football League (NFL) associated with long-term mortality risk?
Findings In this retrospective cohort study of 3812 NFL players who debuted between 1982 and 1992, there was no statistically significant difference in the risk of long-term all-cause mortality among career NFL players compared with NFL replacement players who participated in the NFL during a 3-game league-wide player strike in 1987 (adjusted hazard ratio, 1.38; 95% CI, 0.95-1.99).
Meaning Career participation in NFL football, compared with participation as an NFL replacement player, was not associated with a statistically significant difference in the risk of all-cause mortality.
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